By Katie Harkess, MD
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February 16, 2021
The past year has brought a lot of uncertainty to our lives. Given that pregnancy is already an uncertain time, the unknown surrounding COVID and the COVID vaccine can understandably lead to anxiety. Should you get this vaccine or not? Is the vaccine safe? With this blog, we hope to be able to shed some light on that question. When patients walk into our office, the first question that they often have regarding the vaccine is, “How does this vaccine work?” The COVID vaccines are mRNA vaccines. Because these vaccines are the first mRNA vaccines on the market, there are a lot of questions regarding how they work. The vaccine contains a small amount of genetic material called mRNA. The best way to think about mRNA is as a recipe or as an instruction manual. Once you get the vaccine, the mRNA is taken up by your cells and acts as an instruction manual for your cells to make spike protein, a protein that is found on the COVID virus. Once your cells make the spike proteins, they present them to your immune cells, which then make antibodies against COVID. So, if you contract COVID, your body has the antibodies ready to go to fight the virus! After the mRNA has done its job, it is quickly degraded by your cells. Therefore, there is no evidence that it crosses the placenta. There are two important things to remember when considering these vaccines. First, because this vaccine does not contain a live COVID virus, it cannot give you COVID. In addition, because the mRNA is never taken into your cell’s nucleus, it does not have the ability to change your DNA. This new technology is very exciting because mRNA vaccines give us a much more efficient way to produce vaccines than previous vaccine technology using live or inactivated virus. There have been two vaccines that have been approved for emergency use by the FDA. These vaccines have been produced by Pfizer and Moderna. The Pfizer vaccine is given in two doses 21 days apart and has been approved for use in people ages 16 and older. In the trials, the Pfizer vaccine was found to be 95% effective. To put that in perspective, consider that according to the CDC, the 2019-2020 flu vaccine was 39% effective. The Moderna Vaccine has been approved for people aged 18 and older. It is given in 2 doses 28 days apart and was found to be 94.5% effective in trials. Once you start a vaccine series, you should complete the series using the same manufacturer. Both doses in the series are necessary to receive full protection. If more than 21 or 28 days have passed since your first vaccination, the second dose should be given as soon as possible, but no doses need to be repeated. The natural next question from our patients has been, “Is it safe?” Unfortunately, pregnant women were not included in the COVID vaccine trials. There are further ongoing studies, but the safety data is not yet available. However, the American College of Ob/Gyns, the American Society of Reproductive Medicine, and the Society for Maternal-Fetal Medicine all recommend that women who are trying to conceive, pregnant women and lactating women who are eligible for the vaccine should be offered the vaccine, even if they have previously had COVID. In addition, the current guidelines from these societies do not recommend waiting a specific amount of time to try to conceive after vaccination. But, what does that mean for you? We know that pregnant women are at risk of having more severe disease if they contract COVID-19. Many reports have shown that pregnancy women are 3x more likely to need an ICU admission compared to non-pregnant women if they contract COVID. Depending on your health history and other underlying conditions, your risk of severe disease may be even higher. Thus, when deciding whether or not to receive the vaccine, we must consider four factors: 1) the level of activity of the virus in the community 2) the potential efficacy of the vaccine 3) the risk and potential severity of maternal disease, including the effects of disease on the fetus and newborn and 4) the safety of the vaccine for the pregnant patient and the fetus. Unfortunately, the level of activity in our community is currently high, and we know that both vaccines have about a 95% efficacy rate. Thus, a lot of the decision is likely based on the potential risk of maternal disease and the safety of the vaccine for the pregnant patient. It is important to recognize that because the vaccine does not contain live virus, it is not thought to cause an increase in infertility, miscarriage, stillbirth or congenital abnormalities. Therefore, your individual factors as a patient will often dictate whether or not you receive the vaccine. What are your underlying health conditions that increase your risk of having severe disease? What is your risk of contracting the disease? We recognize that the risk of someone who works from home may be different than the risk of someone who works in healthcare. If you decide to receive the vaccine during pregnancy, when is the best time to get it? At this time, there is not a recommendation for optimal timing of vaccine administration in pregnancy. However, the COVID vaccine should not be given within 14 days of another vaccine, which should be taken into consideration when giving other vaccines in pregnancy. Thus, the influenza and Tdap vaccine should not be given within 14 days of the COVID vaccine. When taking all of these factors into consideration, we encourage you to talk to your provider at your next appointment about whether or not to receive the COVID vaccines and when to receive the vaccine. There is so much individualization that goes into this decision. We know that this is a personal decision, and we encourage you to ask questions and let us help guide you in your decision making. In the meantime, keep up the handwashing, maintain social distance and mask up! As always, we are here for you regarding any COVID or pregnancy-related questions! Katie Harkess, MD